Agranulocytosis from Levamisole-Adulterated Cocaine

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Agranulocytosis from levamisole-adulterated cocaine.

INTRODUCTION Afebrile neutropenia with an absolute neutrophil count (ANC) of zero in a nonimmunocompromised individual is unusual. Outlined is a case of agranulocytosis likely due to levamisole laced cocaine. Given recent publications in the news media and medical journals, this is a pertinent issue for primary care providers. CASE A 57-year-old female presented with painful bowel movements a...

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Pathologic manifestations of levamisole-adulterated cocaine exposure

UNLABELLED Rheumatic manifestations of cocaine have been well described, but more recently, a dramatic increase in the levamisole-adulterated cocaine supply in the United States has disclosed unique pathologic consequences that are distinct from pure cocaine use. Most notably, patients show skin lesions and renal dysfunction in the setting of extremely high perinuclear anti-neutrophil cytoplasm...

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Cutaneous vasculopathy associated with levamisole-adulterated cocaine.

We report a case of cutaneous vasculopathy associated with the use of levamisole-adulterated cocaine. This recently described clinical entity is characterized by a purpuric rash with a predilection for the ears, leukopenia, and anti-neutrophilic cytoplasmic antibody (ANCA) positivity. It is estimated that more than 70% of the current United States cocaine supply is contaminated with levamisole....

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Levamisole-adulterated Cocaine Induced Vasculitis with Skin Ulcerations

CASE REPORT A 40-year-old man with Hepatitis C and a history of cocaine abuse presented with multiple stages of painful rashes on his extremities and ears. On examination, the patient had several areas of purpuric macules and retiform purpura to his legs and ears (Figures 1 and 2), as well as large ulcerations with erythematous borders on bilateral lower extremities (Figure 3). Laboratory studi...

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Antineutrophil cytoplasmic antibody mediated glomerulonephritis associated with levamisole-adulterated cocaine

Levamisole-adulterated cocaine has increased in prevalence over the last decade and is known to be associated with antineutrophil cytoplasmic antibodies (ANCA). Dermatologic manifestations of levamisole exposure, including cutaneous vasculitis, are widely appreciated; less is known about its effects on the kidney. We report two cases of patients with a history of cocaine abuse and levamisole-in...

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ژورنال

عنوان ژورنال: The Journal of the American Board of Family Medicine

سال: 2012

ISSN: 1557-2625,1558-7118

DOI: 10.3122/jabfm.2012.04.110177